1) Biomechanics and mechanobiology of nano- and microscale structures in living systems.
2) Understanding mechanisms of bone functional adaptation by remodeling and regeneration.
3) Multiscale modeling and simulation of actin filament dynamics in cell migration.
4) Elucidation of mechano-biochemical coupling mechanisms in mechanosensory cells.
5) Nano- and microengineering of artificial systems combined with biomolecular and cellular systems.
||Research Subjects and Results
We have been focusing on interactions between mechanical and biochemical factors that are essential for various cellular activities. Continuum and discrete modeling and computational simulations for the multiscale dynamics of actin cytoskeletal system have been conducted for the basic understandings of the complex structure-function relationships in the actin network dynamics. Modeling and simulation studies have been combined with in vitro experiments on the actin dynamics in migrating cells and on the measurements of the force acting on stress fibers and the interactions between actin filaments and their binding proteins. These combinations of in silico and in vitro studies will contribute to the future progress in the cellular and molecular biomechanics.
Our research activities will be focusing on the functional adaptation by remodeling/reorganization in living systems those have mechanical hierarchy in structure-function relationships from the macroscopic organ/tissue levels to the microscopic cell/molecular levels. To clarify their mechanoregulation, we will conduct integrated researches of modeling and simulation combined with experiments by bridging spatiotemporal scales from molecular and cellular activities to tissue behaviors.
||VCAD Public Software
Software Block Page
Self-organizing Optic-cup Morphogenesis in Three-dimensional Culture
「Mototsugu Eiraku, Nozomu Takata, Hiroki Ishibashi, Masako Kawada, Eriko Sakakura, Satoru Okuda, Kiyotoshi Sekiguchi, Taiji Adachi, and Yoshiki Sasai」
Nature, (2011) in press.
Yoshitaka Kameo, Taiji Adachi, Masaki Hojo
「Effects of Loading Frequency on Functional Adaptation of Trabecula Predicted by Bone Remodeling Simulation」
Journal of the Mechanical Behavior of Biomedical Materials, (2011) in press.
Yasuhiro Inoue and Taiji Adachi
「Coarse-grained Brownian Ratchet Model of Membrane Protrusion on Cellular Scale」
Biomechanics and Modeling in Mechanobiology, (2011) in press.
Hiroshi Kamioka, Taiji Adachi
「Application of Bioimaging to Osteocyte Biology」
Clinical Reviews in Bone and Mineral Metabolism, Vol. 8, No. 4, pp. 170-178 (2010).
Shinji Matsushita, Taiji Adachi, Yasuhiro Inoue, Masaki Hojo and Masahiro Sokabe
「Evaluation of Extensional and Torsional Stiffness of Single Actin Filaments by Molecular Dynamics Analysis」
Journal of Biomechanics, Vol. 43, No. 16, pp. 3162-3167 (2010).
Yasuhiro Inoue, Takeji Deji, Yoshitaka F, Masaki Hojo, Taiji Adachi
「Simulations of Dynamics of Actin Filaments by Remodeling Them in Shear Flows,」
Computers in Biology and Medicine, Vol. 40, No. 11/12, pp. 876-882 (2010).
Control of Highly Migratory Cells by Microstructured Surface Based on Transient Change in Cell Behavior
「Hiromi Miyoshi, Jungmyoung Ju, Sang Min Lee; Dong Jin Cho; Jong Soo Ko, Yutaka Yamagata, Taiji Adachi,」
Biomaterials, Vol. 31, No. 33, pp. 8539-8545 (2010).
Taiji Adachi, Yoshitaka Shimada, Yasuhiro Inoue, and Masaki Hojo
「Approach Behavior of Binding Proteins toward Actin Filament (Brownian Dynamics Simulation)」
Transactions of the Japan Society of Mechanical Engineers (in Japanese), Vol. 76, No. 8, pp. 1119-1127 (2010).
Hidetaka Yamaoka and Taiji Adachi
「Continuum Dynamics on a Vector Bundle for a Directed Medium」
Journal of Physics A: Mathematical and Theoretical, Vol. 43, No. 32, pp. 325209 (15pp) (2010).
Taiji Adachi, Yoshitaka Kameo, Masaki Hojo
「Trabecular Bone Remodelling Simulation Considering Osteocytic Response to Fluid-induced Shear Stress」
Philosophical Transactions of the Royal Society A, Vol. 368, pp. 2669-2682 (2010).
Kennedy Omondi Okeyo, Taiji Adachi, Masaki Hojo
「Mechanical Regulation of Actin Network Dynamics in Migrating Cells」
Journal of Biomechanical Science and Engineering, Vol. 5, No. 3, pp. 186-207 (2010).
Yoshitaka Kameo, Taiji Adachi, Narumichi Sato, Masaki Hojo
「Estimation of Bone Permeability Considering Morphology of Lacuno-Canalicular Porosity」
Journal of the Mechanical Behavior of Biomedical Materials, Vol. 3, No. 3, pp. 240-248 (2010).
Hidetaka Yamaoka and Taiji Adachi
「Coupling between Axial Stretch and Bending/twisting Deformation of Actin Filaments Caused by a Mismatched Centroid from the Center Axis」
International Journal of Mechanical Science, Vol. 52, No. 2, pp. 329-333 (2010).
Kennedy O Okeyo, Taiji Adachi, Masaki Hojo
「Dynamic Coupling between Actin Network Flow and Turnover Revealed by Flow Mapping in the Lamella of Crawling Fragments」
Biochemical and Biophysical Research Communications, Vol. 390, No. 3, pp. 797-802 (2009).
Kennedy Omondi Okeyo, Taiji Adachi, Junko Sunaga, Masaki Hojo
「Actomyosin Contractility Spatiotemporally Regulates Actin Network Dynamics in Migrating Cells」
Journal of Biomechanics, Vol. 42, No. 15, pp. 2540-2548 (2009).
Taiji Adachi, Yuki Aonuma, Shin-ichi Ito, Mototsugu Tanaka, Masaki Hojo, Teruko-Takano Yamamoto, and Hiroshi Kamioka
「Osteocyte Calcium Signaling Response to Bone Matrix Deformation」
Journal of Biomechanics, Vol. 42, No. 15, pp. 2507-2512 (2009).
Taiji Adachi, Yuki Aonuma, Keisuke Taira, Masaki Hojo, Hiroshi Kamioka
「Asymmetric Intercellular Communication between Bone Cells: Propagation of the Calcium Signaling」
Biochemical and Biophysical Research Communications, Vol.?389, No. 3, pp. 495-500 (2009).
Yoshitaka Kameo, Taiji Adachi, and Masaki Hojo
「Fluid Pressure Response in Poroelastic Materials Subjected to Cyclic Loading」
Journal of the Mechanics and Physics of Solids, Vol. 57, No. 11, pp. 1815-1827 (2009).
Taiji Adachi, Yuki Aonuma, Mototsugu Tanaka, Masaki Hojo, Teruko Takano-Yamamoto, and Hiroshi Kamioka
「Calcium Response in Single Osteocytes to Locally Applied Mechanical Stimulus: Differences in Cell Process and Cell Body」
Journal of Biomechanics, Vol. 42, No. 12, pp. 1989-1995 (2009).
Yoshitaka Shimada, Taiji Adachi, Yasuhiro Inoue, and Masaki Hojo
「Coarse-grained Modeling and Simulation of Actin Filament Behavior Based on Brownian Dynamics Method」
Molecular and Cellular Biomechanics, Vol. 6, No. 3, pp. 161-173 (2009).
Ken-ichi Tsubota, Yusuke Suzuki, Tomonori Yamada, Masaki Hojo, Akitake Makinouchi, and Taiji Adachi
「Computer Simulation of Trabecular Remodeling in Human Proximal Femur Using Large-Scale Voxel FE Models: Approach to Understanding Wolff’s Law」
Journal of Biomechanics, Vol. 42, No. 8, pp. 1088-1094 (2009).
Taiji Adachi, Kennedy O. Okeyo, Yoshimichi Shitagawa, and Masaki Hojo
「Strain Field in Actin Filament Network in Lamellipodia of Migrating Cells: Implication for Network Reorganization」
Journal of Biomechanics, Vol. 42, No. 3, pp. 297-302 (2009).
Yoshitaka Kameo, Taiji Adachi, and Masaki Hojo
「Transient Response of Fluid Pressure in a Poroelastic Material under Uniaxial Cyclic Loading」
Journal of the Mechanics and Physics of Solids, Vol. 56, No. 5, pp. 1794-1805 (2008).
Taiji Adachi, Katsuya Sato, Norio Higashi, Yoshihiro Tomita, and Masaki Hojo
「Simultaneous Observation of Calcium Signaling Response and Membrane Deformation due to Localized Mechanical Stimulus in Single Osteoblast-like Cells」
Journal of the Mechanical Behavior of Biomedical Materials (JMBBM), Vol. 1, No. 1, pp 43-50 (2008).
Katsuya Sato, Taiji Adachi, Daisuke Ueda, Masaki Hojo, and Yoshihiro Tomita
「Measurement of Local Strain on Cell Membrane at Initiation Point of Calcium Signaling Response to Applied Mechanical Stimulus in Osteoblastic Cell,」
Journal of Biomechanics, Vol. 40, No. 6, pp. 1246-1255. (2007).
Katsuya Sato, Taiji Adachi, Yasuhito Shirai, Naoaki Saito, and Yoshihiro Tomita
「Local Disassembly of Actin Stress Fibers Induced by Selected Release of Intracellular Tension in Osteoblastic Cell」
Journal of Biomechanical Science and Engineering, Vol. 1, No. 1, pp. 204-214 (2006).
Ken-ichi Tsubota and Taiji Adachi
「Computer Simulation Study on Local and Integral Mechanical Quantities at Single Trabecular Level as Candidates of Remodeling Stimuli」
Journal of Biomechanical Science and Engineering, Vol. 1, No. 1, pp. 124-135 (2006).
Taiji Adachi, Yuki Osako, Mototsugu Tanaka, Masaki Hojo, and Scott J. Hollister
「Framework for Optimal Design of Porous Scaffold Microstructure by Computational Simulation of Bone Regeneration」
2006-7, Biomaterials, Vol. 27, No. 21, pp. 3964-3972 (2006).
Selected Publications Page