研究者/開発者/スタッフ紹介
横田秀夫 (Hideo YOKOTA) 横田秀夫 (Hideo YOKOTA)
研究テーマ

生物基盤構築チームの運営

研究内容と成果

イメージベースドモデリング技術を用いた、生命科学分野でのVCADシステムの応用展開
ライブセルモデリングプロジェクトの推進

今後の展望

基幹研究所 先端技術基盤部門に於いて、研究を継続


論文・特許紹介

【論文】
T. Ijiri and H. Yokota
Contour-based Interface for Refining Volume Segmentation
Computer Graphics Forum 29(7), pp.2153?2160 (2011).

K. Maeshima, H. Iino, S. Hihara, T. Funakoshi, A. Watanabe, M. Nishimura, R. Nakatomi, K. Yahata, F. Imamoto, T. Hashikawa, H. Yokota and N. Imamoto
Nuclear Pore Formation, but Not Nuclear Growth, is Governed by Cyclin-dependent Kinases (Cdks) During Interphase in Human Dividing Cells
Nature Structural & Molecular Biology (in printing).

S. Yoshizawa, A. Belyaev and H. Yokota
Curvature Extremalities for Intelligent Shape and Image Interrogation
Proceedings of International Conference on Geometry and Graphics (2010 (accepted)).

S. Yoshizawa, S. Takemoto, M. Takahashi, M. Muroi, S. Kazami, H. Miyoshi and H. Yokota
Interactive Registration of Intracellular Volumes with Radial Basis Functions
International Journal of Computational Intelligence and Applications (2010 (accepted)).

J. Nakanishi, Y. Kikuchi, Y. Tsujimura, H. Nakayama, S. Kaneko, T. Shimizu, K. Yamaguchi, H. Yokota, Y. Yoshida, T. Takarada, M. Maeda and Y. Horiike
Precise patterning of photoactivatable glass coverslip for fluorescence observation of shape-controlled cells
Supramolecular Chemistry 22(7), pp.396?405 (2010).

井尻敬, 高山健志, 横田秀夫, 五十嵐健夫
柔軟物体のためのアニメーションデザイン手法
映像情報メディア学会誌64(2), pp.183-187 (2010).

S. Yoshizawa, A. Belyaev and H. Yokota
Fast Gauss Bilateral Filtering
Computer Graphics Forum: The International Journal of Eurographics Association 29(1), pp.60?74 (2010).

K. Fujisaki, H.Yokota, H. Nakatsuchi, Y. Yamagata, T. Nishikawa, T. Udagawa and A. Makinouchi
Observation of three-dimensional internal structure of steel materials by means of serial sectioning with ultrasonic elliptical vibration cutting
Journal of Microscopy 237(1), pp.89?95 (2010).

K. Fujisaki, H. Yokota, N. Furushiro, Y. Yamagata, T. Taniguchi, R. Himeno, A. Makinouchi and T. Higuchi
Development of ultrafine-grain binderless cBN tool for precision cutting of ferrous materials
Journal of Materials Processing Technology 209(15?16), pp.5646-5652 (2009).

S. Takemoto, H. Yokota, T. Mishima and R. Himeno
Segmentation of Anatomical Structure by Using a Local Classifier Derived from Neighborhood Information
Human-Computer Systems Interaction, Series: Advances in Intelligent and Soft Computing 60, pp.171?180 (2009).

T. Ijiri, K. Takayama, H. Yokota and T. Igarashi
ProcDef: Local-to-global Deformation for Skeleton-free Character Animation
Computer Graphics Forum: The International Journal of Eurographics Association (Proc. of Pacific Graphics) 28(7), pp.1821?1828(2009).

山澤建二, 安齋正博, 横田秀夫, 姫野龍太郎, 鈴木裕, 楢原弘之
粉末積層造形法を用いた人工骨成形法の提案:成形骨の多孔質性
生体医工学47(2), pp.142?147 (2009).

小林大祐,横田秀夫,森下壮一郎,深作和明,平岡和幸,野田茂穂,姫野龍太郎
動脈グラフの閉路の真贋判定法
電子情報通信学会論文誌D J92-D(9), pp.1643?1652 (2009).

J. Kimura, N. Kakusho, K. Yamazawa, Y. Hirano, Y. Nambo, H. Yokota and R. Himeno
Stereolithographic biomodeling of equine ovary based on 3D serial digitizing device
Journal of veterinary science 10(2), pp.161?163 (2009).

森下壮一郎,横田秀夫,橋口博樹,姫野龍太郎,三島健稔
多重蛍光の定量的分析のための独立成分分析による線形性評価に関する研究
電子情報通信学会論文誌D-II J92-D(4), pp.511?520 (2009).

[16] 古城直道, 横田秀夫, 藤崎和弘, 山形豊, 小久保光典, 姫野龍太郎, 牧野内昭武, 樋口俊郎, “試料内部3 次元情報取得システムによ
るアルミニウム合金ダイカスト内部の鋳巣観察”,
精密工学会誌74(9), pp.991?996 (2008).

M. Rajendra, A. Yamamoto, T. Oda, H. Kataoka, H. Yokota, R. Himeno and T. Higuchi
Motion generation in MR environment using electrostatic film motor for motion-triggered cine-MRI
IEEE/ASME Transactions on Mechatronics 13(2), pp.278?285 (2008).

T. Sera, H. Yokota, K. Fujisaki, K. Fukasaku, H. Tachibana, K. Uesugi, N. Yagi and R. Himeno
Development of high-resolution 4D in vivo-CT for visualization of cardiac and respiratory deformations of small animals
Phys Med Biol. 53(16), pp.4285?4301 (2008).

S. Yoshizawa, A. Belyaev, H. Yokota and H.-P. Seidel
Fast, Robust, and Faithful Methods for Detecting Crest Lines on Meshes
Computer Aided Geometric Design (CAGD) 25(8), pp.545?560 (2008).

Y. He, H. Liu, R. Himeno, J. Sunaga, N. Kakusho and H. Yokota
Finite element analysis of blood flow and heat transfer in an imagebased human finger
Comput. Biol. Med. 38(5), pp.555?562 (2008).

古城直道, 横田秀夫, 藤崎和弘, 山形豊, 小久保光典, 姫野龍太郎, 牧野内昭武, 樋口俊郎
逐次精密切削加工による試料内部3 次元情報取得システムの開発
精密工学会誌74(6), pp.587-592 (2008).

K. Yamazawa, M. Anzai, H. Yokota, R. Himeno, H. Suzuki, H. Narahara and S. Suzuki
Trial formation of artificial bone by inkjetpowder-layered manufacturing
International Jurnal of Automation Technology 2(3), pp.156?161 (2008).

M. Ichikawa, Y. Okamura-Oho, K. Shimokawa, S. Kondo, S. Nakamura, H. Yokota, R. Himeno, K.-P. Lesch and Y. Hayashizaki
Expression analysis for inverted effects of serotonin transporter inactivation
Biochemical and Biophysical Research Communications 368, pp.43?49 (2008).

山澤建二, 横田秀夫, 姫野龍太郎, 安齋正博, 鈴木裕, 楢原弘之, 鈴木茂樹
粉末積層造形法を用いた人工骨成形法の提案―成形性の検討―
生体医工学42(2), pp.169?176 (2007).

横田秀夫
情報処理による生命現象の時空間解析手法の開発
実験医学28(1), pp.45?53 (2010, 解説).

高村正人, 横田秀夫, 牧野内昭武
測定データからの力学シミュレーション
精密工学会誌74(11), pp.1249?1255 (2008, 解説).

横田秀夫,姫野龍太郎
生体力学シミュレーションのための人体モデル構築
日本ロボット学会誌26(3), pp.218?221 (2008, 解説).

姫野龍太郎,横田秀夫
生体力学シミュレーション研究シミュレーションのためのボクセル人体モデルの構築
情報処理46(12), pp.1337?1342 (2005, 解説).

横田秀夫,姫野龍太郎
生体形状データベース構築
精密工学会誌71(12), pp.1498-1501 (2005, 解説).

S. Yoshizawa, S. Takemoto, M. Takahashi, M. Muroi, S. Kazami, H. Miyoshi and H. Yokota
Intracellular Volume Registration
International Conference on Intelligent Systems Design and Applications, Pisa, Italy, November 30-December 2, 2009, pp. 1407?1412.

S. Takemoto and H. Yokota
Algorithm Selection for Intracellular Image Segmentation based on Region Similarity
International Conference on Intelligent Systems Design and Applications, Pisa, Italy, November 30-December 2, 2009, pp. 1413?1418.

S. Yoshizawa, A. Belyaev, H. Yokota and H.-P. Seidel
Fast and Faithful Geometric Algorithm for Detecting Crest Lines on Meshes
Pacific Graphics, Maui, Hawaii, October 29-November 2, 2007, pp.231?237.

Y. Nagai, Y. Ohtake, H. Suzuki and H. Yokota
Outlier/Noise-Robust Partition of Unity Implicit Surface Reconstruction
Geometric Computing Workshop on Asian Conference on Design and Digital Engineering, Jeju, Korea, 25?28 August, 2010, pp.454?460.

T. Ijiri and H. Yokota
Contour-based Interface for Refining Volume Segmentation
Pacific Graphics2010, 2010.

S. Yoshizawa, A. Belyaev and H. Yokota
Feature-Preserving Filters for Biomedical Image Denoising and Clustering
Int. Conf. on Systems Biology, Edinburgh, UK, October 10-14, 2010, CD: pp. a189, poster.

S. Takemoto, S. Yoshizawa and H. Yokota
A Performance Prediction System for Automatic Intracellular Image Quantization
Int. Conf. on Systems Biology, Edinburgh, UK, October 10-14, 2010, CD: pp. a194, poster.

T. Koyama, N. Honda, S. Yoshizawa, Y. Sunaga, S. Noda, S. Ishii and H. Yokota
Cell Simulations with Complex 3D Shapes
Int. Conf. on Systems Biology, Edinburgh, UK, October 10-14, 2010, CD: pp. a210, poster.

Y. Sunaga, S. Yoshizawa, S. Noda, T. Koyama, Y. Tsujimura and H. Yokota
A novel simulation platform for cell biochemical reactions, diffusions, and membrane functions
Int. Conf. on Systems Biology, Edinburgh, UK, October 10-14, 2010, CD: pp. a161, poster.

H.Yokota, K. Fujisaki, N. Furushiro, Y. Yamagata and N. Yamashita
Three-dimensional internal structure observation for industrial materials by means of high precision serial sectioning system
Symposium on Processing and Fabrication of Advanced Materials 18 (PFAM XVIII), Sendai, 2009, 12, Invited talk.

S. Takemoto H. Yokota
Parallelized Performance of Image Segmentation Algorithm by using the Linux Cluster on RICC
Super Computing 2009, Oregon, USA, November 14-20, 2009, poster.

S. Morishita, H. Yokota, H. Asama, R. Himeno and T. Mishima
Compensation method for quantitative observation of multicolor fluorescence with nonlinear mapping
Proceedings of SPIE, Mathematics of Data/Image Pattern Recognition, Compression, and Encryption with Applications, San Diego, CA, USA, Aug., 2008, pp. 70750J-1-70750J-10.

S.Takemoto, H.Yokota, R.Himeno and T.Mishima
Segmentation of anatomical structure by using a local classifier derived from neighborhood information
Proc. Of 2008 IEEE International Conference on Human System Interaction, 2008, No.004472.

H. Yokota
Elucidation of life phenomenon using a simulation and imaging - Expectation for atomic technology-
Second International Symposium on Atomic Technology(ISAT2), Awaji, 2007, Invited talk.

H. Yokota, N. Kakusho, K. Mekada, A. Murakami, S. Nakamura, M. Ito, K. Kase, S. Oota, K. Fukami, H. Masuya, S. Wakana, K.Moriwaki, T. Shiroishi, R. Himeno, O. Obata and A. Yoshiki
High-Resolution full color digital mouse anatomy by three-dimensional internal structure microscopy
21st International Mammalian Genome Conferenc, 2008, 140.

A. Yamamoto, M. Rajendra, Y. Hirano, H. Kataoka, H. Yokota, R. Himeno and T. Higuchi
Motion Generation in MRI Using an Electrostatic Linear Motor for Visualizing Internal Deformation of Soft Objects by tagged cine-MRI
Proceedings, 2007 IEEE International Symposium on Industrial Electronics, 2007/6, pp. 2741?2746.

M. Rajendra, A. Yamamoto, H. Kataoka, T. Oda, H. Yokota, Y. Hirano, R. Himeno and T. Higuchi
Application of an Electrostatic Film Motor in MRI-related Biomechanical Measurement
Mechanical Engineering Congress, 2007 Japan (MECJ-07, 2007/9, Vol. 5 , pp. 257?258.

M. Rajendra, A. Yamamoto, T. Oda, H. Yokota, R. Himeno and T. Higuchi
Application of Force Sensor made of Shielded StrainGauges in MR-related Biomechanical Measurements
Proceedings, 8th Conference of System Intergration section (SI2007), 2007/12, Vol. SY0012/07/0000, pp. 1069?1070.

M. Rajendra, A. Yamamoto, T. Oda, H. Kataoka, H. Yokota, Y. Hirano, R. Himeno and T. Higuchi
Electrostatic Linear Actuation System for Motion Generation Inside MRI to Visualize Internal Deformation of Biological Objects
(ISMRM) SMRT 16th Annual Meeting Syllabus, 2007/5, p.319.

Y. Endo, J. Sakamoto, Y. Kashiwano, H. Yokota, S. Nakamura and J. Oda
A biomechanical study on burst mechanism of impatiens pericarps
5th Plant biomechanics conference, 2006, pp.555?560.

H. Yokota, M. NISHIMURA, K. FUKASAKU, S. NODA, H. SHIMAI, S. NAKMURA, R. HIMENO and A. Makinouchi
Construction of Integrated Mechanical Simulation Model of Whole Body for Alive Human
the World Congress on Medical Physics and Biomedical Engineering 2006(WC2006), 2006.

H. Yokota, S. Nakamura and R. HIMENO
Digitization of the internal structure of a biological sample using a 3-dimensional internal structure
The 16th International Microscopy Congress(IMC16), 2006.

【特許】
特願2010-149462
領域データ編集装置,領域データ編集方法,プログラム,及び,記録媒体
井尻敬,横田秀夫

特願2010-149497
画像表示装置,画像表示方法,曲線特定装置
井尻敬,横田秀夫

特願2009-110683
画像処理装置,画像処理方法およびプログラム
竹本智子,横田秀夫

特願2005-248312
遺伝子発現画像構築方法及び遺伝子発現画像構築システム
横田秀夫,於保祐子,下川和郎

EP1935988A1,EU
Method of constructing gene expression image and system for constructing gene expression image
H. Yokota, Y. Oho and K. Shimokawa

US12/065014
Method of constructing gene expression image and system for constructing gene expression image
H. Yokota, Y. Oho and K. Shimokawa

特願2005-062524
多重蛍光からの蛍光色素濃度の推定方法
森下壮一郎, 横田秀夫, 姫野龍太郎, 三島健稔

特願2004-243978
3次元眼底画像の構築・表示装置
孫智剛,横田秀夫,野條忠克,村上幸巳,伊藤撤,姫野龍太郎,牧野内昭武

特願2003-284055
粉末積層法による人工骨成型方法
山澤建二,安西正博,横田秀夫,鈴木茂樹

特許番号:4017157
中空臓器血管抽出方法,中空臓器血管抽出処理プログラムおよび画像処理装置
横田秀夫,竹本智子,三島健稔,牧野内昭武,姫野龍太郎

US10/627979
Method of extraction of region of interest, Image processing apparatus, and computerproduct
H. Yokota, S. Takemoto, T. Mishima, A. Makinouchi and R. Himeno

特許登録番号:7219997 (出願番号:特願2002-189265)
眼底の立体表示および座標計測方法と装置
横田秀夫,牧野内昭武,矢部比呂夫

米国特許:US 7219997B2
Method and apparatus for three dimensionally displaying eyeground and measuring coordinatestherof
H. Yokota, A. Makinouchi and H. Yabe

特願2001-226859
立体カラーコピー方法および装置
横田秀夫,山澤建二

特願2002-57963
生体内発現遺伝子の微細3次元局在の観察方法
横田秀夫,中村佐紀子,牧野内昭武,樋口俊郎,姫野龍太郎

特願2002-57935
生体内発現遺伝子の3次元局在の観察方法およびその装置
横田秀夫,中村佐紀子,吉木淳,牧野内昭武,樋口俊郎,姫野龍太郎

特開2002-148153
3次元内部構造の解析方法及び装置
横田秀夫,牧野内昭武,樋口俊郎

特開平8-35921
試料ブロックおよびその自動検査装置
樋口俊郎,横田秀夫,工藤謙一

特開平9-243561
試料断面観察方法およびその装置
樋口俊郎,横田秀夫

特開平10-026586
試料観察方法およびその装置
樋口俊郎,工藤謙一,横田秀夫,福田祥慎

特開平10-123054
試料観察方法およびその装置
樋口俊郎,工藤謙一,横田秀夫

特開平10-206296
試料支持方法
樋口俊郎,工藤謙一,横田秀夫

特開平10-293095
試料ブロックの製造方法およびその装置
樋口俊郎,工藤謙一,横田秀夫

特開平10-301489
スライサ装置
樋口俊郎,工藤謙一,横田秀夫

特開2000-184322
コマドリ記録装置
樋口俊郎,工藤謙一,横田秀夫

特開2000-176893
スライサ装置
樋口俊郎,工藤謙一,横田秀夫

特開2000-190291
スライサ装置
樋口俊郎,工藤謙一,横田秀夫

特開2000-198096
スライサ装置
樋口俊郎,工藤謙一,横田秀夫

特開2000-221124
スライサ装置におけるデータ取り込み方法
樋口俊郎,工藤謙一,横田秀夫

特開2000-199734
スライサ装置
樋口俊郎,工藤謙一,横田秀夫

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