研究者/開発者/スタッフ紹介
坪田健一 坪田健一


研究テーマ

骨梁リモデリングの計算バイオメカニクス

研究内容と成果

VoxelFEMを用いた大規模シミュレーションにより,細胞スケールのリモデリングが組織スケールの機能的適応能をもたらすプロセスを明らかにした.

今後の展望

力学モデリングとシミュレーションを駆使して、生体組織の機能的適応メカニズムの理解を進める。

VCAD公開ソフトウェア

V-BoneRemodeling

ブロック全体図へ


論文・特許紹介

【論文】
Tsubota, K., Suzuki, Y., Yamada, T., Hojo, M., Makinouchi, A. and Adachi, T.
Computer Simulation of Trabecular Remodeling in Human Proximal Femur Using Large-Scale Voxel FE Models: Approach to Understanding Wolff's Law
Journal of Biomechanics, Vol. 42, No. 8, pp. 1088-1094 (2009)

Tsubota, K. and Adachi, T.
Simulation Study on Local and Integral Mechanical Quantities at Single Trabecular Level as Candidates of Remodeling Stimuli
Journal of Biomechanical Science and Engineering, Vol. 1, No. 1, pp. 124-135 (2006)

Tsubota, K. and Adachi, T.
Spatial and Temporal Regulation of Cancellous Bone Structure: Characterization of a Rate Equation of Trabecular Surface Remodeling
Medical Engineering and Physics, Vo. 27, No. 4, pp. 305-311 (2005)

Tsubota, K. and Adachi, T.
Changes in the Fabric and Compliance Tensors of Cancellous Bone due to Trabecular Surface Remodeling, Predicted by a Digital Image-Based Model
Computer Methods in Biomechanics and Biomedical Engineering, Vol. 7, No. 4, pp. 187-192 (2004)

Tsubota, K., Adachi, T. and Tomita, Y.
Effects of a Fixation Screw on Trabecular Structural Changes in a Vertebral Body Predicted by Remodeling Simulation
Annals of Biomedical Engineering, Vol. 31, No. 6, pp. 733-740 (2003)

Tsubota, K., Adachi, T. and Tomita, Y.
Functional Adaptation of Cancellous Bone in Human Proximal Femur Predicted by Trabecular Surface Remodeling Simulation toward Uniform Stress State
Journal of Biomechanics, Vol. 35, No. 12, pp. 1541-1551 (2002)

Adachi, T., Tsubota, K., Tomita, Y. and Hollister, S. J.,
Trabecular Surface Remodeling Simulation for Cancellous Bone Using Microstructural Voxel Finite Element Models
Transactions of the ASME, Journal of Biomechanical Engineering, Vol. 123, No. 5, pp. 403-409 (2001)

論文、特許一覧ページへ